SCIENTIFIC ADVISORY BOARD

DR. ANDREW HERR, PHD
Dr. Herr was instrumental in the creation and development of the BioLexa Platform, so we are honored to have him on our advisory board and grateful for his assistance to the Company. According to the National Eczema Association, this chronic skin condition affects approximately 32 million Americans and is a multibillion dollar market in the U.S. alone. We are excited to be working towards improving the lives of those affected.”

Dr. Andrew Herr, PhD, is an associate professor in the Division of Immunobiology and Center for Systems Immunology, with an affiliate appointment in the Division of Infectious Diseases at Cincinnati Children’s Hospital within the UC Department of Pediatrics. Dr. Herr completed his thesis work in molecular biophysics from Washington University in St. Louis, and completed his postdoctoral work in structural immunology at the California Institute of Technology as a Damon Runyon Research Fellow. He was recruited to the University of Cincinnati College of Medicine as an Ohio Eminent Scholar in Structural Biology before moving to Cincinnati Children’s Hospital.

The Herr lab studies mechanisms of bacterial pathogenesis. Specifically, they discovered the zinc-dependent mechanism of intercellular adhesion in bacterial biofilms formed by Staphylococcus epidermidis and S. aureus. Biofilms are specialized bacterial colonies that are highly resistant to antibiotics and immune responses, so developing novel therapies to prevent biofilm formation is of high importance. This is of particular significance in eczema, since nearly 90% of people who suffer from atopic dermatitis are colonized by S. aureus on their skin. Dr. Herr also solved the first structure of a human IgA1 antibody bound to its cognate Fc receptor while at Caltech, and his lab has continued to study antibodies and immune receptors implicated in autoimmune diseases. In addition, the lab is studying a family of related collagen-specific immune receptors such as glycoprotein VI, which activates platelets upon exposure to fibrous collagen. Before joining the faculty at Cincinnati Children’s within the University of Cincinnati College of Medicine, Dr. Herr was an Ohio Eminent Scholar in Structural Biology at the University of Cincinnati College of Medicine and served as an associate director of the Cincinnati Medical Scientist (MD/PhD) Training Program. Dr. Herr received the 2014 Emerging Entrepreneurial Achievement Faculty Award from UC for his work to commercialize a novel anti-infective therapy based on his lab’s research.

RICHARD D. GRANSTEIN, M.D.
Dr. Granstein is one of the nation’s most esteemed dermatologist and the current Chairman of the Department of Dermatology at Weill Cornell Medical Center. His extensive and prestigious background studying skin disorders will be invaluable to the Company in our attempt to bring relief to the approximately 32 million Americans suffering from eczema.”

Richard D. Granstein, M.D. is the George W. Hambrick, Jr. Professor and Chairman of the Department of Dermatology. Dr. Granstein obtained his undergraduate education at the Massachusetts Institute of Technology and his medical education at the UCLA School of Medicine. After completing his internship in 1979, he trained in dermatology at the Massachusetts General Hospital. As a Research Fellow, Dr. Granstein studied immunology and tumor biology at the National Cancer Institute-Frederick Cancer Research Facility and at Harvard Medical School. Dr. Granstein joined the faculty of the Department of Dermatology at Harvard Medical School and the Massachusetts General Hospital in 1984. In 1995 he left Harvard to become Chairman of the Department of Dermatology at the Weill Medical College of Cornell University and Dermatologist-in-Chief at the NewYork-Presbyterian/Weill Cornell Medical Center.

Dr. Granstein’s research interests center on the regulation of immunity within the skin and the relationship of the skin’s immune system to the development of skin cancers. He also has a special research interest in the regulation of the immune system by stress and the nervous system. He was the first to demonstrate that certain immune cells within the skin are capable of initiating an immune response against a malignant tumor and that immune cells within the epidermis (the upper layer of the skin) have an anatomic relationship with nerves and can be regulated by proteins produced by those nerves. His clinical interests include autoimmune disorders of the skin, skin cancer, and psoriasis.

ROBERT J. VANDER ZANDEN, PH.D.
Dr. Robert J. Vander Zanden, having served as a Vice President of R&D with Kraft Foods International, brings a long and distinguished career in applied technology, product commercialization, and business knowledge to Hoth Therapeutics. In his 30-year career, he has been with ITT Continental Baking Company as a Product Development Scientist; with Ralston Purina’s Protein Technology Division as Manager Dietary Foods R&D; with Keebler as Group Director, Product and Process Development; with Grupo Gamesa, a Frito-Lay Company, as Vice President, Technology; and with Nabisco as Vice President of R&D for their International Division. With the acquisition of Nabisco by Kraft Foods, he became the Vice President of R&D for Kraft’s Latin American Division. Dr. Vander Zanden retired from Kraft Foods in 2004. He currently holds the title of Adjunct Professor and Lecturer in the Department of Food, Nutrition, and Packaging Sciences at Clemson University, where he also is a member of their Industry Advisory Board. His focus on achieving product and process innovation through training, team building and creating positive working environments has earned him multiple awards for product and packaging innovation. Dr. Vander Zanden holds a Ph.D. in Food Science and an M.S. in Inorganic Chemistry from Kansas State University, and a B.S. in Chemistry from the University of Wisconsin – Platteville, where he was named a Distinguished Alumnus in 2002.

JONATHAN HALE ZIPPIN M.D., Ph.D.
Jonathan Hale Zippin M.D., Ph.D. is an Associate Professor of Dermatology and Pharmacology and an Associate Attending Dermatologist at Weill Medical College of Cornell University. Dr. Zippin is the current Vice Chair of Research in the Department of Dermatology and is the Director of the Contact, Occupational, and Photo Dermatitis Unit. Dr. Zippin obtained his undergraduate education at Cornell University where he received a Bachelor’s of Science with Honors. He then attended the Rockefeller/Cornell/Sloan-Kettering Tri-Institutional M.D./Ph.D. program. After completing a general medicine internship at the Mount Sinai Hospital in New York City, he trained in dermatology at the Weill Cornell Medical Center – New York Presbyterian Hospital. Following completion of his post-doctoral studies in 2010, Dr. Zippin joined the faculty of the Department of Dermatology at Weill Cornell Medical College.

Dr. Zippin is a member of the American Academy of Dermatology, the Society for Investigative Dermatology, and the American Contact Dermatitis Society. He also serves on the Board of Directors of the American Contact Dermatitis Society where he helps to direct national policy on the treatment and detection of allergic-based eczema. Dr. Zippin serves as a consultant or medical advisor to companies, reviews papers for journals, and has helped to found companies based on his intellectual property.Dr. Zippin has authored numerous peer-reviewed publications in the area of signal transduction and skin disease, and has published a variety of papers reviewing the treatment of dermatologic diseases. Dr. Zippin’s research interests focus on understanding the signaling mechanisms that regulate diseases such as psoriasis, eczema, and melanoma with a specific focus on cAMP signaling. His clinical interests are focused on improving the detection and treatment of allergy based diseases of the skin.

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