Hoth Therapeutics

We are committed to the patient experience by following the science to develop impactful and versatile treatment solutions for everyone. At HOTH, we stand by our mission to innovate today for a better tomorrow.

Learn more about our therapeutic areas, Early Access program, as well as ongoing and future clinical trial opportunities.

If you have questions regarding our clinical trials, please contact us here.

Current Development

HT-KIT Injection

Mast Cell Derived Cancers

HT- KIT is a New Molecular Entity – classified as Antisense Oligonucleotide (ASO). It directly targets and inhibits the proto-oncogene c-KIT (including mutations in cKIT) providing a broad range of potential therapeutic indications: Aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL); Acute myeloid leukemia (AML); Gastrointestinal stromal tumors (GIST); Small lung cell carcinoma. It also has a secondary indication for the prevention of anaphylaxis. HT-KIT received Orphan Designation in 2022 for treatment of mastocytosis. API manufacturing and formulation development has been initiated.

Expanded Access
& Compassionate Use

We understand that there are critically ill patients who will not meet all of the criteria to enroll in our clinical trials and don’t have options for alternative therapies.