BioLexa Topical Agent
WHAT IS BIOLEXA?
BioLexa is a patented, proprietary antimicrobial topical formulation being developed for treatment of diseases mediated by Staphylococcal biofilms. Bacterial biofilms are specialized, communities consisting of bacteria adhered to a surface (both biological and abiotic surfaces) and to other bacteria, and often with a protective extracellular matrix. Mature bacterial biofilms often result in chronic, recurrent infections that are difficult to treat due to the barrier effect of the biofilm that facilitates antibiotic resistance and avoiding immune system mechanisms. The BioLexa formulation is optimized to prevent Staphylococcal biofilm formation, keeping the bacteria in a more susceptible state to antimicrobial therapy. This novel mechanism of action has the potential to broadly treat clinical manifestations resulting from Staphylococcal biofilm formation.
BioLexa topical agent is under development for the following indications:
- Atopic dermatitis (eczema)
- Aesthetic dermatology
- Surgical site infections
- Chronic/diabetic wound care
DEVELOPMENT STATUS: CLINICAL STAGE
IND-enabling preclinical studies completed in 2020. Phase 1b/2a study in patients with atopic dermatitis is targeted to be initiated Q1 2021.
PUBLICATION & NEWS
UNIVERSITY OF MIAMI STUDY
The University of Miami tested the ability of BioLexa’s DTPA chelator to synergize with the antibiotic in an animal study. Specifically, the pre-clinical study introduced high levels of Staph bacteria to wounds on the skin of pigs, as pig skin is the closet animal model to human skin. The results, as set forth in this chart, show significant reduction in bacterial infection. In some cases, the bacterial count was below detectable levels.