HT-005 Z-Pods™

WHAT ARE HT-005 Z-PODS™?

HOTH has entered a partnership agreement with Zylö Therapeutics Inc to co-develop a new topical treatment for patients with Cutaneous Lupus Erythematosus (CLE), a chronic autoimmune disease that affects the skin and is associated with a significant burden on patient quality of life. Therapeutic options for CLE are limited to steroids (topical and oral), topical calcineurin inhibitors, and other immunomodulating therapies that could have adverse effects during long-term use.

HT-005 Z-Pods™ includes a novel topical delivery matrix (Z-Pods™) loaded with an endogenous ligand with suspected immune-modulating action. Z-Pods™ use patented xerogel-derived nanoparticles for sustained and controlled topical delivery of active pharmaceutical ingredients.

For more information on the Z-Pod™ technology, please visit http://www.zylotherapeutics.com/

DEVELOPMENT STATUS

The HT-005 Z-Pods™ product is currently in the early preclinical stage of development.

INVESTOR RELATIONS

Hoth Therapeutics seeks to enhance shareholder value not only through business performance and practices, but also through responsible and effective communication with its shareholders.